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FOCUS

The research group LQPN (Laboratório de Química de Produtos Naturais) is active in the area of:

• Herbal medicine,
• Plants natural products,
• Fungal natural products,
• Functional food.
• Mushroom natural products.

We use techniques of purification and isolation to identify  biologically active substances from medicinal plants. We also develop and validate analytical methods (LC-ESI-MS, GCMS, HPLC, etc) to search as guided by popular knowledge for new natural substances from herbals and food residues. These substances are therefore evaluated for their antileishmanial, antitrypanosomal, anti-inflammatory, antimicrobial and antiproliferative activities.

OBJECTIVES:

• Extraction and isolation of natural products.
• Chemical analysis of complex mixtures (e.g. plant extracts, human fluids) and secondary metabolites (e.g. alkaloids, terpenoids, or flavonoids) using a wide range of chromatographic or spectroscopic-based phytochemical analytical tools such as LC-ESI-MS, NMR techniques, GC-MS.
• Structural elucidation and identification of natural products.
• Chemical fingerprinting using dereplication, molecular networking and metabolic profiling techniques.
• Search of pharmacological valuable compounds in crude extracts.
• Develop synthetic and semisynthetic analogues of natural products.